Desarrollan un fármaco contra el Alzheimer sin secuelas inflamatorias

Desarrollan un fármaco contra el Alzheimer sin secuelas inflamatorias

Un equipo de investigadores del KAIST en Corea del Sur ha desarrollado un novedoso fármaco de proteína de fusión, aAB-Gas6, que elimina eficazmente el AB, importante en la enfermedad de Alzheimer, a través de un mecanismo totalmente diferente al de la inmunoterapia basada en anticuerpos AB.

En un modelo de ratón de la EA, aAB-Gas6 no sólo eliminó el AB con mayor potencia, sino que también evitó los efectos secundarios inflamatorios neurotóxicos asociados a los tratamientos convencionales con anticuerpos.

Aunque ‘Aduhelm’, un anticuerpo monoclonal dirigido a la beta amiloide (AB), se ha convertido recientemente en el primer fármaco aprobado en Estados Unidos frente a la enfermedad de Alzheimer (EA) por su capacidad para disminuir la carga de la placa AB en pacientes con EA, su efecto en la mejora cognitiva sigue siendo controvertido.

Además, alrededor del 40 por ciento de los pacientes tratados con este anticuerpo experimentaron efectos secundarios graves, como edemas cerebrales (ARIA-E) y hemorragias (ARIA-H) que probablemente están relacionados con las respuestas inflamatorias en el cerebro cuando el anticuerpo AB se une a los receptores Fc (FCR) de células inmunitarias como la microglía y los macrófagos.

Estos efectos secundarios inflamatorios pueden causar la muerte de células neuronales y la eliminación de sinapsis por parte de la microglía activada, e incluso tienen el potencial de exacerbar el deterioro cognitivo en los pacientes con EA. Así pues, la actual inmunoterapia basada en anticuerpos contra AB tiene el riesgo inherente de hacer más daño que bien debido a sus efectos secundarios inflamatorios.

“La activación del FcR por parte de los anticuerpos dirigidos a AB induce la fagocitosis de AB mediada por la microglía, pero también produce señales inflamatorias, dañando inevitablemente los tejidos cerebrales”, explican Chan Hyuk Kim y Won-Suk Chung, autores del estudio, que se ha publicado en la revista científica ‘Nature Medicine’.

El efecto antiinflamatorio de usar la eferocitosis

Por lo tanto, utilizaron la eferocitosis, un proceso celular por el que los fagocitos eliminan las células muertas como vía alternativa para la eliminación de AB en el cerebro. La eferocitosis va acompañada de respuestas antiinflamatorias para mantener la homeostasis de los tejidos.

“Para explotar este proceso, diseñamos Gas6, una proteína adaptadora soluble que media la eferocitosis a través de los receptores fagocíticos TAM de tal manera que su especificidad de destino se redirigió de las células muertas a las placas de AB”, detallan los responsables del trabajo.

Los profesores y su equipo demostraron que la aAB-Gas6 resultante inducía la engullición de AB activando no sólo la fagocitosis microglial, sino también la astrocítica, ya que los receptores fagocíticos TAM son altamente expresados por estos dos fagocitos principales en el cerebro.

Es importante destacar que aAB-Gas6 promovió la captación robusta de AB sin mostrar ningún signo de inflamación y neurotoxicidad, lo que contrasta fuertemente con el tratamiento utilizando un anticuerpo monoclonal AB.

Además, demostraron que el aAB-Gas6 reducía sustancialmente la eliminación excesiva de sinapsis por parte de la microglía, lo que conducía a una mejor recuperación del comportamiento en los ratones modelo de la EA.

“Utilizando un modelo de ratón de angiopatía amiloide cerebral (AAC), un trastorno cerebrovascular causado por el depósito de AB dentro de las paredes de los vasos sanguíneos del cerebro, también demostramos que la administración intratecal de la proteína de fusión Gas6 eliminaba significativamente los amiloides cerebrovasculares, junto con una reducción de las microhemorragias. Estos datos demuestran que el aAb-Gas6 es un potente agente terapéutico para eliminar el AB sin exacerbar las microhemorragias relacionadas con la AAC”, esgrimen.

69 comentarios

I recently tried CBD gummies in requital for the cardinal heyday and I forced to https://www.cornbreadhemp.com/collections/full-spectrum-cbd-oil say, I’m impressed with the results. I felt more nonchalant and at aid, and my worry was significantly reduced. The gummies tasted considerable and were tranquil to consume. I’ll for all be using them again and would propose them to anyone looking for a accepted procedure to alleviate accentuate and anxiety.

Pingback: tizanidine 2023
Pingback: lisinopril prices
Pingback: buy fluoxetine
Pingback: prednisone price
Pingback: promethazine 2023

I walked into the headshop with a mix of snooping and trepidation. dab rig The walls were lined with shelves and pageantry cases filled with colorful pipes, bongs, and other smoking accessories. The aura was like that with the friendly smell of incense, and reggae music played softly in the background. A clubby counter-jumper greeted me and asked if I needed help find anything. I admitted that I was a suspicion overwhelmed past the range, and he offered to reveal me some of their best-selling items. As he pulled gone from a lustrous, euphonious vaporizer, he explained how it worked and the benefits of using it beyond old smoking methods. He also showed me a batch of flavored rolling papers and a grinder with a chill design. I ended up leaving with a occasional items, awareness stimulated to struggle exposed my fashionable purchases. The judgement had been surprisingly enjoyable, and I was impressed by way of the knowledgeable and on good terms staff. I couldn’t wait to happen back and enquire into more of what the headshop had to offer.

I walked into the headshop with a socialize of meddlesomeness and trepidation. cheap bongs The walls were lined with shelves and display cases filled with colorful pipes, bongs, and other smoking accessories. The air was compressed with the sweet whiff of incense, and reggae music played softly in the background. A clubby shop assistant greeted me and asked if I needed assist verdict anything. I admitted that I was a bit overwhelmed during the set, and he offered to manifest me some of their best-selling items. As he pulled short a lustrous, silverware vaporizer, he explained how it worked and the benefits of using it beyond time-honoured smoking methods. He also showed me a pick of flavored rolling papers and a grinder with a chill design. I ended up leaving with a occasional items, appreciation excited to essay absent from my new purchases. The taste had been surprisingly enjoyable, and I was impressed by way of the well-educated and warm-hearted staff. I couldn’t be put on ice to happen following and enquire into more of what the headshop had to offer.

I recently tried CBD gummies recompense the basic moment and I’m opportune to communicate full spectrum cbd oil that I’m a fan. The gummies tasted excessive and helped me feel more languid and focused. I have discompose sleeping at night, but these gummies helped me collar a more restful sleep. I’m excited to keep on using them and explore other CBD products. Extremely favour for anyone looking to look after accent and put take!

I tried CBD gummies someone is concerned the first age and I was pleasantly surprised. They tasted great https://discovercbd.com/products/cbg-oil and helped me see more devil-may-care and at ease. I suffer from habitual pain and establish that the gummies or helped to alleviate some of my irritation without any negative side effects. I when one pleases surely be purchasing these gummies again and would approve them to anyone looking proper for a fitting spirit to take care of spasm and stress.

I recently tried CBD Products https://www.trythecbd.com/products/ for the start with time and I forced to assert, I’m impressed with the results. I felt more devil-may-care and at ease, and my foreboding was significantly reduced. The CBD gummies tasted pronounced and were relaxing to consume. I’ll obviously be using them again and would counsel them to anyone looking an eye to a regular more to alleviate worry and anxiety.

Most of those cliimate changes are attriibuted to very small variations in Earth’s orbit that change the quantity
of photo voltaic vitality our planwt receives.
Traveling to the suitable place brings in a nice change and is a good anti-depressant as
effectively. Republicans are attempting to finish democracy in AmericaThere are two histrories of voting in thee United States,
there was thoise who attempt to see that each citizen has
a prroper to vote and there has been those who have strive
to restrict the variety of voters too those who will favor their candidate or causes.
Conservatives have used every little thing from a poll
tax to removing voters from the votijg rolls to limt who votes, ten-hour waiting lines
have been the norm in many of those pink states.
The United States was based as a hybrid government with is a republic with democratic representation,
free enterprise some occasions wrongly confused with
capitalism and what we might name democratic socialism.

In these trying occasjons when life can seem so heavy, when joy apppears as a forgot time memory, when life is little
more than a burden there may be hope.

Take a look at myy website :: https://courtneysheaescort.com/citys/Discreet-apartments-in-Givatayim.php

Check out our selection at Massage Unlimited for the perfect massage chairs.
This Ayurvedic oil is the ost effective child massage oils for sturdy bones.
If you want to avail the advantages of Ayurvedic Abhyanga Massage, you need to goo to Pure Herbwl Ayurved Clinic in Melbourne.

In accordance with Ayurvedic massages are a
different form of healing which is thought today.
Slowly add water until you type a glue that is smooth.
People today barely get ime off from their hectic schedues to take plleasure in some quiet tiume in solitude, or with
their loved ones. Relieve some stress while within the hands
of an expert aromatherapy master being totally relaxed and at the identical time doing fagors to your
pores and skin and physique. Yoou must take your time and educate
your self. Carrot oil: Rich in vitamnins and can also be used as a very glod tanning
lotion, as it lessens thee skin sensitivity to sunlight, mix small quantity (10%) aas thee shiny orange color may stain ones skin.

My web page :: https://exoticsenualoriental.com/categor/Discreet-apartments-in-Nes-Ziona.php

Deja una respuesta

Tu dirección de correo electrónico no será publicada. Los campos obligatorios están marcados con *

0
EL CARRITO
  • No products in the cart.