Medically reviewed by Melissa Badowski, PharmD, MPH, FCCP — By Jennifer Mitri Williamson, Pharm.D. — Updated on September 12, Learn about .However, an excess of this will have most of the blood rushing toward the penis, which causes it to engorge and swell up. The blue pill works by inhibiting an enzyme called phosphodiesterase type 5 PDE-5 , making muscles in the penis more likely to relax, and allow blood to flow in, causing an erection. How oral medicines differ Each oral medicine for ED has a slightly different chemical makeup. Less blue pills is more when it comes to healthy sexual function. It works for up to 36 hours.Oral medicines for ED usually work well and cause few side effects. The four main medicines taken by mouth for erectile dysfunction are: Avanafil (Stendra). Sildenafil . Medically reviewed by Melissa Badowski, PharmD, MPH, FCCP — By Jennifer Mitri Williamson, Pharm.D. — Updated on September 12, Learn about .Generic versions of sildenafil, vardenafil and tadalafil are available. Too much can cause a priapism, an uncomfortable and disproportionately large erection that lasts for more than four hours. Your doctor or other health care professional can recommend one for you based on these factors, other health conditions you have and any other medicines you take. Often, these are prescribed for chest pain called angina. It might work longer if you have mild to moderate erectile dysfunction. Oral medicine for ED also might not be safe or work well if you have: Very low blood pressure, called hypotension, or uncontrolled high blood pressure, called hypertension.
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